Quality of Research
Documents Reviewed
The documents below were reviewed for Quality of Research. The research point of
contact can provide information regarding the studies reviewed and the availability
of additional materials, including those from more recent studies that may have been conducted.
Study 1Gregory, R. J., Chlebowski, S., Kang, D., Remen, A. L., Soderberg, M. G., Stepkovitch, J., et al. A controlled trial of psychodynamic psychotherapy for co-occurring borderline personality disorder and alcohol use disorder. Psychotherapy: Theory, Research, Practice, Training, 45(1), 28-41.
Gregory, R. J., DeLucia-Deranja, E., & Mogle, J. A. Dynamic Deconstructive Psychotherapy versus optimized community care for borderline personality disorder co-occurring with alcohol use disorders: A 30-month follow-up. Journal of Nervous and Mental Disease, 198(4), 292-298. Study 2Gregory, R. J., Mustata, G. T., & Deranja, E. Six-month outcomes of Dynamic Deconstructive Psychotherapy vs Dialectical Behavior Therapy for borderline PD at a university clinic. Unpublished manuscript, Upstate Medical University, State University of New York.
Supplementary Materials Goldman, G. A., & Gregory, R. J. Preliminary relationships between adherence and outcome in Dynamic Deconstructive Psychotherapy. Psychotherapy: Theory, Research, Practice, Training, 46(4), 480-485.
Goldman, G. A., & Gregory, R. J. Relationships between techniques and outcomes for borderline personality disorder. American Journal of Psychotherapy, 64(4), 359-371.
Linehan, M. M., Comtois, K. A., Brown, M. Z., Heard, H. L., & Wagner, A. Suicide Attempt Self-Injury Interview (SASII): Development, reliability, and validity of a scale to assess suicide attempts and intentional self-injury. Psychological Assessment, 18(3), 303-312.
Pfohl, B., Blum, N., St. John, D., McCormick, B., Allen, J., & Black, D. W. Reliability and validity of the Borderline Evaluation of Severity Over Time (BEST): A self-rated scale to measure severity and change in persons with borderline personality disorder. Journal of Personality Disorders, 23(3), 281-293.
Outcomes
| Outcome 1: Symptoms of borderline personality disorder |
|
Description of Measures
|
Symptoms of borderline personality disorder were measured using the Borderline Evaluation of Severity Over Time (BEST), a 15-item self-report measure with three subscales: negative thoughts and feelings, negative behaviors, and positive behaviors. The BEST is used to assess the degree of impairment or interference from each of the DSM-based diagnostic symptoms of borderline personality disorder. For example, the item "Worrying that someone important in your life is tired of you or is planning to leave you" is rated on a 5-point scale from "none/slight" to "extreme." The combined score ranges from 12 to 72, with higher scores representing greater impairment due to borderline personality disorder symptoms.
|
|
Key Findings
|
In a randomized clinical trial, adults diagnosed with borderline personality disorder and active alcohol abuse or dependence were assigned either to a group receiving DDP or to a control group receiving optimized community care (e.g., given referrals to alcohol rehabilitation centers and provided with the names of psychiatric clinics and therapists in the community). Treatment with DDP was discontinued for all patients between 12 and 18 months after initial enrollment in the trial. The BEST was administered at baseline and at 3-, 6-, 9-, 12-, and 30-month follow-up. Compared with control group participants, DDP participants had significantly lower BEST scores at 12-month follow-up (38.4 vs. 33.6; p < .05). Over time, from baseline through 30-month follow-up, DDP participants had a significantly greater decrease in BEST scores than control group participants (p = .027), a difference associated with a large effect size (Cohen's d = 1.31).
In another study, patients diagnosed with borderline personality disorder were assigned to a group receiving DDP, a group receiving comprehensive Dialectical Behavior Therapy (DBT), or a control group receiving optimized community care (e.g., receiving weekly individual therapy that was unstructured and psychodynamically oriented). The BEST was administered at baseline and at 6-month follow-up. At 6-month follow-up, DDP participants had significantly lower BEST scores (33.2) than DBT participants (42.7; p = .025) and control group participants (40.0; p = .02), after controlling for differences in baseline severity and age. These group differences were associated with medium and large effect sizes (Cohen's d = 0.74 and 1.1, respectively).
|
|
Studies Measuring Outcome
|
Study 1, Study 2
|
|
Study Designs
|
Experimental, Quasi-experimental
|
|
Quality of Research Rating
|
3.3
(0.0-4.0 scale)
|
| Outcome 2: Depression |
|
Description of Measures
|
Depression was measured using the Beck Depression Inventory (BDI), a 21-item self-report instrument. Each item presents statements relating to a symptom of depression, with each statement rated on a scale from 0 to 3. Total scores range from 0 to 63, with higher scores representing more severe depression.
|
|
Key Findings
|
In a randomized clinical trial, adults diagnosed with borderline personality disorder and active alcohol abuse or dependence were assigned either to a group receiving DDP or to a control group receiving optimized community care (e.g., given referrals to alcohol rehabilitation centers and provided with the names of psychiatric clinics and therapists in the community). Treatment with DDP was discontinued for all patients between 12 and 18 months after initial enrollment in the trial. The BDI was administered at baseline and at 3-, 6-, 9-, 12-, and 30-month follow-up. Compared with control group participants, DDP participants had significantly lower BDI scores at 12-month follow-up (25.1 vs. 21.0; p < .05). Over time, from baseline through 30-month follow-up, DDP participants had a significantly greater decrease in BDI scores than control group participants (p = .007), a difference associated with a large effect size (Cohen's d = 1.25).
In another study, patients diagnosed with borderline personality disorder were assigned to a group receiving DDP, a group receiving comprehensive Dialectical Behavior Therapy (DBT), or a control group receiving optimized community care (e.g., receiving weekly individual therapy that was unstructured and psychodynamically oriented). The BDI was administered at baseline and at 6-month follow-up. At 6-month follow-up, DDP participants had significantly lower BDI scores (17.3) than DBT participants (21.7; p = .005) and control group participants (26.3; p = .01), after controlling for differences in baseline severity and age.
|
|
Studies Measuring Outcome
|
Study 1, Study 2
|
|
Study Designs
|
Experimental, Quasi-experimental
|
|
Quality of Research Rating
|
3.5
(0.0-4.0 scale)
|
| Outcome 3: Parasuicide behaviors |
|
Description of Measures
|
Parasuicide behaviors were measured using the Lifetime Parasuicide Count (LPC), a structured interview that assesses the frequency of parasuicide behaviors, including overdoses, cutting, and burning. Participants indicate the behaviors they have engage in, and for each, whether they were "intending to die," "ambivalent," or "not intending to die." The LPC contains the same items regarding frequency and intent of parasuicide behavior as the Suicide Attempt Self-Injury Interview (SASII). Assessment occurred at baseline and at 3-, 6-, 9-, 12-, and 30-month follow-up.
|
|
Key Findings
|
In a randomized clinical trial, adults diagnosed with borderline personality disorder and active alcohol abuse or dependence were assigned either to a group receiving DDP or to a control group receiving optimized community care (e.g., given referrals to alcohol rehabilitation centers and provided with the names of psychiatric clinics and therapists in the community). Treatment with DDP was discontinued for all patients between 12 and 18 months after initial enrollment in the trial. Over time, from baseline through 30-month follow-up, DDP participants had a significantly greater decrease in parasuicide behaviors than control group participants (p = .002), a difference associated with a medium effect size (Cohen's d = 0.52).
|
|
Studies Measuring Outcome
|
Study 1
|
|
Study Designs
|
Experimental
|
|
Quality of Research Rating
|
3.0
(0.0-4.0 scale)
|
| Outcome 4: Heavy drinking |
|
Description of Measures
|
The Addiction Severity Index (ASI) was used to measure heavy drinking, defined as drinking five or more drinks on a single occasion, in the past 30 days. The ASI is a structured interview with seven domains: medical, legal, employment, drug, alcohol, family, and psychological functioning. Assessment occurred at baseline and at 3-, 6-, 9-, 12-, and 30-month follow-up.
|
|
Key Findings
|
In a randomized clinical trial, adults diagnosed with borderline personality disorder and active alcohol abuse or dependence were assigned either to a group receiving DDP or to a control group receiving optimized community care (e.g., given referrals to alcohol rehabilitation centers and provided with the names of psychiatric clinics and therapists in the community). Treatment with DDP was discontinued for all patients between 12 and 18 months after initial enrollment in the trial. At 12-month follow-up, DDP participants reported significantly fewer days of heavy drinking than control group participants (p = .04). There was no statistically significant difference between groups over time from baseline through 30 months.
|
|
Studies Measuring Outcome
|
Study 1
|
|
Study Designs
|
Experimental
|
|
Quality of Research Rating
|
3.4
(0.0-4.0 scale)
|
Study Populations
The following populations were identified in the studies reviewed for Quality of
Research.
|
Study
|
Age
|
Gender
|
Race/Ethnicity
|
|
Study 1
|
18-25 (Young adult)
26-55 (Adult)
|
80% Female
20% Male
|
90% White
3.3% American Indian or Alaska Native
3.3% Black or African American
3.3% Hispanic or Latino
|
|
Study 2
|
18-25 (Young adult)
26-55 (Adult)
55+ (Older adult)
|
78.6% Female
21.4% Male
|
89.3% White
10.7% Race/ethnicity unspecified
|
Quality of Research Ratings by Criteria (0.0-4.0 scale)
External reviewers independently evaluate the Quality of Research for an intervention's
reported results using six criteria:
For more information about these criteria and the meaning of the ratings, see Quality of Research.
|
Outcome
|
Reliability
of Measures
|
Validity
of Measures
|
Fidelity
|
Missing
Data/Attrition
|
Confounding
Variables
|
Data
Analysis
|
Overall
Rating
|
|
1: Symptoms of borderline personality disorder
|
3.5
|
3.5
|
3.0
|
3.6
|
3.5
|
2.9
|
3.3
|
|
2: Depression
|
4.0
|
4.0
|
3.0
|
3.6
|
3.5
|
2.9
|
3.5
|
|
3: Parasuicide behaviors
|
2.5
|
2.5
|
3.0
|
3.6
|
3.5
|
3.1
|
3.0
|
|
4: Heavy drinking
|
4.0
|
4.0
|
3.0
|
3.5
|
3.5
|
2.5
|
3.4
|
Study Strengths The BEST, BDI, and ASI are gold-standard instruments widely used with psychiatric patient populations. Both studies included a manual-driven approach as well as individualized competency assessment and weekly supervision of therapists. The sample sizes were comparable to those in other studies of similar populations, and attrition rates were good considering the population. The researchers were conservative in accounting for missing data and either carried forward most recent observations or used mean substitution, which can increase power and decrease type II error (the failure to detect a significant effect). In one study, randomization procedures resulted in two treatment groups similar in demographics and baseline measures. Both studies used an intent-to-treat analysis, with one of the studies using a modified analysis to ensure a minimum "dose" of treatment in all groups.
Study Weaknesses The LPC, which measures parasuicide behaviors, has limited published data on reliability and validity. No evidence of intervention fidelity was provided through use of an independently tested fidelity instrument. In one study, the attrition rate in one group was almost twice that of the other groups, and there was some baseline variance between groups in the severity of symptoms. Small sample sizes did not allow for more rigorous statistical testing of intervention efficacy in either of the studies.
|
|